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Squamous Cell Head and Neck Cancer : David J. Adelstein :
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Gorges, T. Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition. Mostert, B. CD49f-based selection of circulating tumor cells CTCs improves detection across breast cancer subtypes. Cancer Lett. Pecot, C. Cancer Discov. Raimondi, C. Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients.
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Balm, A. Cytokeratin 18 expression in squamous cell carcinoma of the head and neck. Eur Arch Otorhinolaryngol.
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Hudis, C. Proposal for standardized definitions for efficacy end points in adjuvant breast cancer trials: the STEEP system. CRC press Koutsilieris, M. Repetitive and site-specific molecular staging of prostate cancer using nested reverse transcriptase polymerase chain reaction for prostate specific antigen and prostate specific membrane antigen. Clin Exp Metastasis. Sawabata, N. Circulating tumor cells in peripheral blood caused by surgical manipulation of non-small-cell lung cancer: pilot study using an immunocytology method.
Gen Thorac Cardiovasc Surg. Lembessis, P. Combined androgen blockade therapy can convert RT-PCR detection of prostate-specific antigen PSA and prostate-specific membrane antigen PSMA transcripts from positive to negative in the peripheral blood of patients with clinically localized prostate cancer and increase biochemical failure-free survival after curative therapy. Clin Chem Lab Med. Download references. All of the authors were involved in revision of the manuscript and approved the final version of the manuscript. Correspondence to Marcelo De Carvalho Bittencourt.
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Article metrics. Advanced search. Skip to main content. Subjects Diagnostic markers Head and neck cancer Prognostic markers. Abstract Several techniques have been developed to detect circulating tumor cells CTC in patients with head and neck squamous cell carcinoma HNSCC , but their diagnostic and prognostic value are not yet fully established.
Introduction In cancer diseases, tumor cells eventually detach from the primary site and disseminate in the blood, the lymphatic fluid, the bone marrow or even in the cerebrospinal fluid. Materials and Methods Literature search A computerized retrieval of literature was conducted without time restrictions using the electronic database in December Eligibility Criteria Inclusion criteria 1 original research published in a peer-reviewed journal; 2 only English language papers were included; 3 to avoid ambiguity in the definition of CTC, only techniques using peripheral blood but not bone marrow or other body fluids of patients were considered eligible; 4 patients with histologically confirmed squamous cell carcinoma originating from sphere of head and neck i.
Exclusion criteria 1 other sources of data, i. Statistical Analysis Diagnostic accuracy variables [i. Results Study characteristics As shown in Fig. Figure 1: Flow diagram of the strategy used for the selection of reports. Bi-specific T cell-engaging antibodies BiTEs bind both cancer cells and T cells in order to help the immune system respond more quickly and effectively.
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Antibody targets under evaluation in head and neck cancer clinical trials include:. Cancer vaccines are designed to elicit an immune response against tumor-specific or tumor-associated antigens, encouraging the immune system to attack cancer cells bearing these antigens. Cancer vaccines can be made from a variety of components, including cells, proteins, DNA, viruses, bacteria, and small molecules.
Cancer vaccine targets under evaluation in head and neck cancer clinical trials include:. Natural killer cells NKs and tumor infiltrating lymphocytes TILs can also be enhanced and reinfused in patients. Cell-based immunotherapy targets under evaluation in head and neck cancer clinical trials include:. Checkpoint inhibitors target molecules on immune cells to unleash new or enhance existing immune responses against cancer. Cytokines regulate immune cell maturation, growth, and responsiveness. Adjuvants can stimulate pathways to provide longer protection or produce more antibodies.
Immunomodulator targets under evaluation in head and neck cancer clinical trials include:. Oncolytic virus therapy uses modified viruses that can infect tumor cells and cause them to self-destruct. This can attract the attention of immune cells to eliminate the main tumor and potentially other tumors throughout the body. Viral platforms under evaluation in head and neck cancer clinical trials include:. Create a profile and fill out a questionnaire to identify immunotherapy clinical trials for which you may be eligible. ET Se habla espanol.
jordants.org/components/hide/mathematical-olympiad-treasures.php Consult a healthcare professional about your treatment options. We spoke with Susanne Baumeister, M. Immunotherapy for Head and Neck Cancer. Immunotherapy Immunotherapy by Cancer Type. Let's spread the word about Immunotherapy! Click to share this page with your community. Copy Link. Reviewed By: Andrew Sikora, M. Old found evidence to link the Epstein-Barr virus EBV and nasopharyngeal cancer, giving the field one of the earliest indications of a bridge between a virus and human cancer. Featured Patient.
Featured Scientist. Head and Neck Cancer Clinical Trial Targets Discover the different proteins, pathways, and platforms that scientists and physicians are pursuing to develop new cancer treatments. Cell-based immunotherapy targets under evaluation in head and neck cancer clinical trials include: Epstein-Barr Virus EBV -related antigens: foreign viral proteins expressed by EBV-infected cancer cells MAGE antigens: the genes that produce these proteins are normally turned off in adult cells, but can become reactivated in cancer cells, flagging them as abnormal to the immune system.
Viral platforms under evaluation in head and neck cancer clinical trials include: Adenovirus: a family of common viruses that can cause a wide range of typically mild effects including sore throat, fatigue, and cold-like symptoms Herpes simplex virus: a virus that can cause the formation of sores on the mouth and genitals Measles virus: a highly contagious virus that infects the respiratory tract and can cause measles Reovirus: a family of viruses that can affect the gastrointestinal and respiratory tracts in a range of animal species Vesicular stomatitis virus: a virus that belongs to the same family as the rabies virus; can cause flu-like symptoms in humans.
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